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with carbon-ion microbeamSakashita, Tetsuya; Suzuki, Michiyo; Hamada, Nobuyuki*; Fukamoto, Kana; Yokota, Yuichiro; Funayama, Tomoo; Kobayashi, Yasuhiko
no journal, ,
To investigate the neurogenesis-independent effects of ionizing radiation on the nervous system, we have used a nematode, , in adult. Recently, we found the modulatory effects of 
-rays on the salt chemotaxis learning in 
. Biological effectiveness is known to differ with the linear energy transfer (LET) of radiation: A high-LET radiation causes more dense ionization along their trajectories, and induces more serious biological effects, compared with low-LET radiations such as -rays. Thus, this study aims to address the effects of high-LET carbon ions on the salt chemotaxis learning in . Moreover, localized ionizing irradiation is a useful probe to analyzing radiation effects at a cellular or tissue level. To investigate the effects on the neuronal tissue (a nerve ring), we used the heavy-ion microbeam system at the Takasaki Ion accelerators for Advanced Radiation Application (TIARA) of JAEA.
Kamiya, Tomihiro; Oikawa, Masakazu*; Sato, Takahiro; Kashiwagi, Hirotsugu; Shimada, Hirofumi*; Arakawa, Kazuo; Yusa, Ken*; Nakano, Takashi*
no journal, ,
Funayama, Tomoo; Sakashita, Tetsuya; Fukamoto, Kana; Yokota, Yuichiro; Suzuki, Michiyo; Kobayashi, Yasuhiko
no journal, ,
We had developed the heavy-ion microbeam system at TIARA of the JAEA-Takasaki, and utilized for analyzing heavy-ion induced biological effects. The collimating heavy-ion microbeam system at JAEA-Takasaki has provided target irradiation of heavy charged particles to biological material at atmospheric pressure using a minimum beam size 5 
m in diameter. A variety of biological material has been irradiated using this microbeam system including cultured mammalian and higher plant cells, isolated fibers of mouse skeletal muscle, silk-worm (
) embryos and larvae, 
roots, and the nematode . The system has been applied and contributed to the investigation of mechanisms within biological organisms not only in the context of radiation biology, but also in the fields of general biology such as physiology, developmental biology and neurobiology.
Yokota, Yuichiro; Funayama, Tomoo; Hamada, Nobuyuki*; Sakashita, Tetsuya; Kobayashi, Yasuhiko
no journal, ,
High-LET heavy ions have a greater biological effect than low-LET photon radiation in normal tissues and tumors. In this study, we investigated the cell-killing effect of light- to heavy-ions in normal human fibroblasts to elucidate the mechanism underlying the great effects of heavy ions. Normal human diploid fibroblasts were kept as a confluent cell monolayer and irradiated with -rays (LET=0.2 keV/m), proton (2.8 keV/m), helium (17 keV/m), carbon (70 and 110 keV/m), neon (310 and 430 keV/m) and argon ions (1320 and 1530 keV/m). D
values of -rays, proton, helium, carbon, neon and argon ions were 4.3 Gy, 3.2 Gy, 2.4 Gy, 1.0 Gy, 1.4-1.6 Gy and 3.7-5.0 Gy, respectively. RBE based on the D values arrived at the maximum of 4.3 at 70 and 110 keV/m, indicating that the cell-killing effect of carbon ions per dose was fourfold greater than that of -rays.
Kawachi, Naoki; Watanabe, Shigeki; Fujimaki, Shu; Ishioka, Noriko; Sato, Takahiro; Kamiya, Tomihiro; Arakawa, Kazuo; Watanabe, Shin*; Takeda, Shinichiro*; Ishikawa, Shinnosuke*; et al.
no journal, ,
Yamaguchi, Mitsutaka*; Arakawa, Kazuo; Aono, Hiroyuki*; Ishikawa, Shinnosuke*; Kamiya, Tomihiro; Kawachi, Naoki; Odaka, Hirokazu*; Sakurai, Hideyuki*; Sato, Takahiro; Shimada, Hirofumi*; et al.
no journal, ,
Yamaguchi, Mitsutaka*; Kawachi, Naoki; Watanabe, Shin*; Odaka, Hirokazu*; Takeda, Shinichiro*; Ishikawa, Shinnosuke*; Aono, Hiroyuki*; Takahashi, Tadayuki*; Arakawa, Kazuo; Nakano, Takashi*
no journal, ,
Yoshida, Yukari*; Shimada, Hirofumi*; Kawachi, Naoki; Takeda, Shinichiro*; Ishikawa, Shinnosuke*; Aono, Hiroyuki*; Suzuki, Yoshiyuki*; Sakurai, Hideyuki*; Watanabe, Shin*; Yamaguchi, Mitsutaka*; et al.
no journal, ,
Suzuki, Yoshiyuki*; Yoshida, Yukari*; Shimada, Hirofumi*; Kato, Hiroyuki*; Sakurai, Hideyuki*; Kawachi, Naoki; Takeda, Shinichiro*; Ishikawa, Shinnosuke*; Aono, Hiroyuki*; Watanabe, Shin*; et al.
no journal, ,
no abstracts in English
Br-
-bromobenzylgianidine (Br-MBBG)Watanabe, Shigeki; Hanaoka, Hirofumi*; Liang, J. X.; Iida, Yasuhiko*; Endo, Keigo*; Ishioka, Noriko
no journal, ,
Iida, Yasuhiko*; Hanaoka, Hirofumi*; Yoshioka, Hiroki*; Takayanagi, Megumi*; Watanabe, Shigeki; Ishioka, Noriko; Watanabe, Satoshi; Matsuhashi, Shimpei; Paudyal, P.*; Higuchi, Tetsuya*; et al.
no journal, ,